What Is NAD+?
Last reviewed:
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell — it is not a peptide. It carries electrons in redox metabolism and serves as the substrate for signalling enzymes including sirtuins, PARPs and CD38. The NAD+ described here is a laboratory reference material.
How is NAD+ classified and what is its structure?
NAD+ is a dinucleotide: an adenine nucleotide and a nicotinamide nucleotide joined through their phosphate groups. The molecule cycles between oxidised (NAD+) and reduced (NADH) forms, which is the basis of its role in cellular redox chemistry.
How are NAD+’s roles studied in research?
Beyond redox reactions, NAD+ is consumed as a substrate by sirtuin deacylases, PARP DNA-repair enzymes and the NADase CD38, linking its availability to signalling and genome-maintenance research. Cellular NAD+ is replenished mainly through the NAMPT-dependent salvage pathway, a heavily studied node in metabolism research.
These are biochemical roles measured in laboratory systems; they are not claims about administering NAD+ to people.
What kind of research has been published on NAD+?
Major reviews cover NAD+ metabolism and its roles in cellular processes during ageing (2021), its pathophysiologic mechanisms (2020), brain-specific NAD+ biology (2019) and its regulation of metabolic signalling pathways (2021). The primary literature spans yeast, rodent and human-cell systems.
What compounds is NAD+ studied alongside?
NAD+ research frequently involves its precursors — nicotinamide, nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) — and the enzyme NNMT, which diverts nicotinamide away from NAD+ salvage and is the target of 5-Amino-1MQ.
How is NAD+ supplied, tested and handled?
Lazarus Labs supplies NAD+ 500MG as a laboratory reference material with third-party batch documentation and a Certificate of Analysis (COA). Store cold, dry and protected from light in accordance with your laboratory protocol.
References
- Covarrubias AJ, Perrone R, Grozio A, Verdin E Nature Reviews Molecular Cell Biology. 2021. PMID: 33353981.
- Xie N, Zhang L, Gao W, et al. Signal Transduction and Targeted Therapy. 2020. PMID: 33028824.
- Lautrup S, Sinclair DA, Mattson MP, Fang EF Cell Metabolism. 2019. PMID: 31577933.
- Amjad S, Nisar S, Bhat AA, et al. Molecular Metabolism. 2021. PMID: 33609766.
Primary literature, verified against PubMed. Citations are provided for scientific reference and do not imply a human-use indication.
Important
For research use only. Not for human or veterinary consumption. NAD+ is supplied solely as a laboratory reference material. Lazarus Labs makes no therapeutic, medical or performance claims, and nothing on this page is medical advice.