What Is 5-Amino-1MQ?
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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT) — it is not a peptide. It is studied in cell and animal models examining NNMT enzymology and NAD+-linked metabolic signalling. Evidence for 5-Amino-1MQ remains preclinical.
How is 5-Amino-1MQ classified and what is its structure?
5-Amino-1MQ is 5-amino-1-methylquinolinium, a methylquinolinium salt selected for membrane permeability in the medicinal-chemistry programme that first characterised it. Because it is a quinolinium small molecule rather than an amino-acid chain, it is listed on Lazarus Labs as a research material, not a research peptide.
How is 5-Amino-1MQ’s mechanism studied in research?
NNMT transfers a methyl group from SAM to nicotinamide, producing 1-methylnicotinamide and diverting nicotinamide away from NAD+ salvage. Published assays measure NNMT inhibition, cellular 1-MNA levels and downstream NAD+ and SAM changes in cell systems.
These are biochemical readouts under defined laboratory conditions, not demonstrations of a clinical outcome.
What kind of research has been published on 5-Amino-1MQ?
The 2018 Biochemical Pharmacology paper characterised membrane-permeable NNMT inhibitors, including effects in a diet-induced obesity mouse model. Later work has used the compound in a cervical-cancer cell-line proliferation assay (2021) and in a mouse study combining NNMT inhibition with a reduced-calorie diet (2022).
What compounds is 5-Amino-1MQ studied alongside?
Because its target sits inside NAD+ metabolism, 5-Amino-1MQ appears in the same literature as NAD+ and its precursors (nicotinamide, NMN, NR). These groupings describe shared pathways in published research; they do not imply equivalence or any human-use indication.
How is 5-Amino-1MQ supplied, tested and handled?
Lazarus Labs supplies 5-Amino-1MQ 10MG as a laboratory reference material with third-party batch documentation and a Certificate of Analysis (COA). Store cold, dry and protected from light in accordance with your laboratory protocol.
References
- Neelakantan H, Vance V, Wetzel MD, et al. Biochemical Pharmacology. 2018. PMID: 29155147.
- Akar S, Duran T, et al. Journal of Obstetrics and Gynaecology. 2021. PMID: 33645410.
- Dimet-Wiley A, et al. Scientific Reports. 2022. PMID: 35013352.
Primary literature, verified against PubMed. Citations are provided for scientific reference and do not imply a human-use indication.
Important
For research use only. Not for human or veterinary consumption. 5-Amino-1MQ is supplied solely as a laboratory reference material. Lazarus Labs makes no therapeutic, medical or performance claims, and nothing on this page is medical advice.