What Is TB-500?
Last reviewed:
TB-500 is the research name used for synthetic thymosin beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide first characterised in thymus tissue. Its core biology is actin binding: Tβ4 is the main G-actin-sequestering peptide in mammalian cells. Evidence for TB-500 remains predominantly preclinical.
How is TB-500 classified and what is its structure?
Thymosin beta-4 is a 43-amino-acid member of the beta-thymosin family of small acidic peptides. Its central actin-binding motif (including the LKKTETQ sequence) is responsible for the monomeric-actin binding that defines the family’s biochemistry.
Commercial “TB-500” material in the research market corresponds to synthetic Tβ4 or fragments of it; the Lazarus Labs COA states exactly what each batch contains.
How is TB-500’s mechanism studied in research?
The defining mechanism is actin sequestration: Tβ4 binds monomeric G-actin and holds it out of filament formation, a relationship characterised biochemically in the early 1990s. Because actin dynamics sit underneath cell movement and cytoskeletal remodelling, Tβ4 appears widely in cell-migration and tissue-model research.
What kind of research has been published on TB-500?
Foundational biochemistry (1992) established the actin interaction. Reviews of the beta-thymosin family (2001, 2007) cover the wider biology, and a 2015 review summarises the basic and clinical research directions for Tβ4, including ophthalmic and cardiac research programmes. Clinical development remains investigational.
What compounds is TB-500 studied alongside?
In the tissue-repair research field, Tβ4 is most often grouped with BPC-157, and both appear together in the Lazarus Labs KLOW blend. These groupings describe the published field, not equivalence or any human-use indication.
How is TB-500 supplied, tested and handled?
Lazarus Labs supplies TB-500 10MG as a lyophilised laboratory reference material with third-party batch documentation and a Certificate of Analysis (COA). Store cold, dry and protected from light in accordance with your laboratory protocol.
References
- Weber A, Nachmias VT, Pennise CR, et al. Biochemistry. 1992. PMID: 1627561.
- Huff T, Muller CS, Otto AM, et al. International Journal of Biochemistry & Cell Biology. 2001. PMID: 11311852.
- Hannappel E Annals of the New York Academy of Sciences. 2007. PMID: 17468232.
- Goldstein AL, Kleinman HK Expert Opinion on Biological Therapy. 2015. PMID: 26096726.
Primary literature, verified against PubMed. Citations are provided for scientific reference and do not imply a human-use indication.
Important
For research use only. Not for human or veterinary consumption. TB-500 is supplied solely as a laboratory reference material. Lazarus Labs makes no therapeutic, medical or performance claims, and nothing on this page is medical advice.