What Is Semax?
Semax is a synthetic peptide analogue of a fragment of adrenocorticotropic hormone (ACTH 4–10), studied in neuropeptide and neurotrophic-signalling research. It is an investigational research compound and is not an approved medicine in Australia.
Classification and structure
Semax is a synthetic heptapeptide derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), modified with a C-terminal Pro-Gly-Pro sequence intended to improve its stability. In the literature it is grouped with the neuropeptide research compounds.
Mechanism studied in research
Semax has been examined in neurobiological research, primarily in animal models:
- Neurotrophin signalling — studied in relation to brain-derived neurotrophic factor (BDNF) and its receptor TrkB.
- Neuropeptide activity — investigated as a stabilised ACTH(4–10) fragment.
- Gene expression — examined for effects on neurotrophin-related transcription in brain tissue.
Published research characterises these effects in laboratory and animal-model systems.
These statements describe the published scientific record; they are not claims about any effect in humans.
Research background
Semax was developed from research on ACTH fragments and has since been studied in neuropeptide and neurotrophic-signalling research, largely in animal models. As an investigational compound it remains a subject of ongoing study. Findings are reported in the primary scientific literature listed below.
Purity, testing and handling
Lazarus Labs supplies Semax as a lyophilised (freeze-dried) reference material, independently tested to 99%+ purity, with a batch Certificate of Analysis (COA) available. Lyophilised peptides are typically stored cold and protected from light, in line with standard laboratory practice for reference materials.
References
- Dolotov OV, et al. Brain Research. 2006. PMID: 16996037.
- Dolotov OV, et al. Journal of Neurochemistry. 2006. PMID: 16635254.
Primary literature, verified against PubMed. Citations are provided for scientific reference and do not imply any human-use indication.
Important
For research use only. Not for human or veterinary consumption. Semax is an investigational compound and is not an approved therapeutic good in Australia. Lazarus Labs supplies it solely as a laboratory reference material and makes no therapeutic, medical or performance claims. Nothing on this page is medical advice or a recommendation to administer this compound to humans or animals.