What Is Semax?

How is Semax classified and what is its structure?

Semax is a synthetic heptapeptide derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), modified with a C-terminal Pro-Gly-Pro sequence intended to improve its stability. In the literature it is grouped with the neuropeptide research compounds.

How is Semax’s mechanism studied in research?

Semax has been examined in neurobiological research, primarily in animal models:

• Neurotrophin signalling — studied in relation to brain-derived neurotrophic factor (BDNF) and its receptor TrkB.
• Neuropeptide activity — investigated as a stabilised ACTH(4–10) fragment.
• Gene expression — examined for effects on neurotrophin-related transcription in brain tissue.

Published research characterises these effects in laboratory and animal-model systems.

These statements describe the published scientific record; they are not claims about any effect in humans.

What kind of research has been published on Semax?

Semax was developed from research on ACTH fragments and has since been studied in neuropeptide and neurotrophic-signalling research, largely in animal models. The animal-model literature is still active: a 2025 study in Acta Naturae examined Semax and a Semax derivative in a transgenic Alzheimer’s-model mouse line, and a 2025 cellular study in the Bulletin of Experimental Biology and Medicine investigated its action on intracellular calcium dynamics in rat neurons. As an investigational compound it remains a subject of ongoing study. Findings are reported in the primary scientific literature listed below.

What compounds is Semax studied alongside?

In the published literature, Semax is studied within the same regulatory-peptide research programme as Selank, with one functional-connectivity study examining the two side by side, and a 2024 animal-model study tested it together with melanotan II as a fellow synthetic ACTH(4–10) analogue. These groupings describe how the compounds are classified in published research; they do not imply equivalence between compounds or any human-use indication.

How is Semax supplied, tested and handled?

Lazarus Labs supplies Semax as a lyophilised (freeze-dried) reference material, independently tested to 99%+ purity, with a batch Certificate of Analysis (COA) available. Lyophilised peptides are typically stored cold and protected from light, in line with standard laboratory practice for reference materials.